8,861 research outputs found

    Life cycle assessment of Swiss organic farming systems

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    The impacts of organic and integrated farming systems in Switzerland on the environment have been assessed in a comprehensive study by the life cycle assessment method. This paper reports a comparison of the treatments of the DOC experiment. Organic farming showed clear ecological advantages particularly for eco- and human toxicity, resource use and biodiversity. These ecological advantages only partly apply to nutrient losses and are not always found for single products. Per kg of organic product, higher impacts were often found for global warming potential, ozone formation, eutrophication and acidification compared to integrated production. In the same crop rotation with the same amount of organic fertilisers there were no systematic differences in soil quality of organic compared with integrated production. Further improvement of the environmental performance of organic farming should focus on achieving higher yields of good quality – especially in potatoes and cereals - by using inputs more efficiently and minimising nitrogen losses

    Alien Registration- Dubois, Joseph O. (Sanford, York County)

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    https://digitalmaine.com/alien_docs/2688/thumbnail.jp

    Exact time dependent Hopf solitons in 3+1 dimensions

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    We construct an infinite number of exact time dependent soliton solutions, carrying non-trivial Hopf topological charges, in a 3+1 dimensional Lorentz invariant theory with target space S^2. The construction is based on an ansatz which explores the invariance of the model under the conformal group SO(4,2) and the infinite dimensional group of area preserving diffeomorphisms of S^2. The model is a rare example of an integrable theory in four dimensions, and the solitons may play a role in the low energy limit of gauge theories.Comment: 4 pages revtex, 2 eps figures, replaced with one reference adde

    Relationship between clustering and algorithmic phase transitions in the random k-XORSAT model and its NP-complete extensions

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    We study the performances of stochastic heuristic search algorithms on Uniquely Extendible Constraint Satisfaction Problems with random inputs. We show that, for any heuristic preserving the Poissonian nature of the underlying instance, the (heuristic-dependent) largest ratio αa\alpha_a of constraints per variables for which a search algorithm is likely to find solutions is smaller than the critical ratio αd\alpha_d above which solutions are clustered and highly correlated. In addition we show that the clustering ratio can be reached when the number k of variables per constraints goes to infinity by the so-called Generalized Unit Clause heuristic.Comment: 15 pages, 4 figures, Proceedings of the International Workshop on Statistical-Mechanical Informatics, September 16-19, 2007, Kyoto, Japan; some imprecisions in the previous version have been correcte

    Characterising QT interval prolongation in early clinical development: a case study with methadone

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    Recently, we have shown how pharmacokinetic-pharmacodynamic (PKPD) modelling can be used to assess the probability of QTc interval prolongation both in dogs and humans. A correlation between species has been identified for a drug-specific parameter, making it possible to prospectively evaluate non-clinical signals. Here, we illustrate how nonclinical data on methadone can be used to support the evaluation of prodromic drug effects in humans. ECG and drug concentration data from safety pharmacology study in dogs were analysed using nonlinear mixed effects modelling. The slope of the PKPD model describing the probability of QT interval prolongation was extrapolated from dogs to humans and subsequently combined with methadone pharmacokinetic data as input for clinical trial simulations. Concentration vs. time profiles were simulated for doses between 5 and 500 mg. Predicted peak concentrations in humans were then used as reference value to assess the probability of an increase in QTc interval of ≥ 5 and ≥10 ms. Point estimates for the slope in dogs suggested low probability of ≥10 ms prolongation in humans. However, an effect of approximately 5 ms increase is predicted when accounting for the 90% credible intervals the drug-specific parameter in dogs. In addition, our analysis show that understanding of interspecies differences in drug disposition is required to accurately predict the QT prolonging effects in humans. Extrapolation of the effects of parent compound may not be sufficient to describe the increase in QT interval observed after administration of methadone in humans. Assessment of the contribution of enantioselective metabolism and active metabolites is critical

    Yang-Mills gauge anomalies in the presence of gravity with torsion

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    The BRST transformations for the Yang-Mills gauge fields in the presence of gravity with torsion are discussed by using the so-called Maurer-Cartan horizontality conditions. With the help of an operator \d which allows to decompose the exterior spacetime derivative as a BRST commutator we solve the Wess-Zumino consistency condition corresponding to invariant Chern-Simons terms and gauge anomalies.Comment: 24 pages, report REF. TUW 94-1

    AMBER on the VLTI: data processing and calibration issues

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    We present here the current performances of the AMBER / VLTI instrument for standard use and compare these with the offered modes of the instrument. We show that the instrument is able to reach its specified precision only for medium and high spectral resolution modes, differential observables and bright objects. For absolute observables, the current achievable accuracy is strongly limited by the vibrations of the Unit Telescopes, and also by the observing procedure which does not take into account the night-long transfer function monitoring. For low-resolution mode, the current limitation is more in the data reduction side, since several effects negligible at medium spectral resolution are not taken into account in the current pipeline. Finally, for faint objects (SNR around 1 per spectral channel), electromagnetic interferences in the VLTI interferometric laboratory with the detector electronics prevents currently to get unbiased measurements. Ideas are under study to correct in the data processing side this effect, but a hardware fix should be investigated seriously since it limits seriously the effective limiting magnitude of the instrument.Comment: 10 page
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